A chemist and biologist talk to each other about caged neurotransmitters

• Graham C.R. Ellis-Davies

Beilstein J. Org. Chem. 2013, 9, 64–73, doi:10.3762/bjoc.9.8

• between the two communities to further the creative development and application of these powerful optical probes. Keywords: caged compounds; cell signaling; electrophysiology; neuronal currents; photolabile neurotransmitters; rates of reaction; receptor antagonism; Introduction The first biologically

• genetically encoded indicators actually use the “weaknesses”. Some photolabile neurotransmitters have now been developed and are commercially available without any testing of any sort being performed. Thus, they cannot even really be called “caged”. Biologist: Is your caged transmitter "water soluble